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NCLEX-style review · Independent learning

ABG Academy + Drug Math

Start with simple acid–base patterns, work up to mixed disorders, or switch to medication calculations. All questions are randomized and explained after grading.

Study tool only. Not for medication preparation, prescribing, or patient-care decisions. Verify any ABG interpretation, formula, units, administration requirements, and dose against current clinical sources and institutional policies. Enter no real patient information.

Beginner — four basic disorders

No mixed cases · compensation made simple · no PaO₂
Case 10 / 0 correct
Practice ABG
pH—7.35–7.45
PaCO₂—35–45 mmHg
HCO₃⁻—22–26 mEq/L
Tip: pH tells acid versus base. PaCO₂ runs opposite pH; bicarbonate (HCO₃⁻) moves in the same direction as pH. A return to normal-range pH suggests compensation in the classroom method.

Choose your interpretation

In beginner mode, use the simplified NCLEX classroom convention; real compensation is more precise than these three labels.

Quick-reference guide

Respiratory acidosis
↑ PaCO₂ → ↓ pH
Think hypoventilation/CO₂ retention.
Respiratory alkalosis
↓ PaCO₂ → ↑ pH
Think hyperventilation/CO₂ loss.
Metabolic acidosis
↓ HCO₃⁻ → ↓ pH
Think loss of base / gain of acid.
Metabolic alkalosis
↑ HCO₃⁻ → ↑ pH
Think excess base / acid loss.
Compensation explained

Uncompensated (classroom shorthand): secondary value has not visibly moved to oppose the primary pH change. Partial: secondary value changes appropriately but pH remains outside 7.35–7.45. Compensated: pH is within its reference range despite a primary disorder. In real patients, expected compensation must be calculated; an apparently normal pH can hide two primary disorders.

Expected compensation (Intermediate / Advanced)

Metabolic acidosis: Winter’s predicted PaCO₂ ≈ 1.5 × HCO₃⁻ + 8 (±2). Metabolic alkalosis: expected PaCO₂ ≈ 40 + 0.7 × (HCO₃⁻ − 24) (rough estimate). Acute respiratory acidosis: HCO₃⁻ rises ~1 mEq/L for each 10 mmHg CO₂ rise; chronic ~3–4. Acute respiratory alkalosis: HCO₃⁻ falls ~2 per 10 mmHg CO₂ drop; chronic ~4–5. A response outside expectations suggests mixed disease.

Why PaO₂ is Advanced-only

PaO₂ measures oxygenation, not whether the primary acid–base problem is respiratory or metabolic. A low PaO₂ can coexist with any of these patterns. PaO₂ interpretation depends on age, FiO₂, altitude, and clinical context; the examples assume room air and a sea-level setting.

Reference material: Merck Manual: primary changes and compensation; American Thoracic Society: ABG interpretation. Not endorsed by these organizations. †Typical adult PaO₂ at sea level on room air; contextual interpretation required.